Increased severity of gentamicin nephrotoxicity in aging rats is mediated by a reduced glomerular nitric oxide production.
Environ Toxicol Pharmacol
; 2(1): 73-5, 1996 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-21781704
ABSTRACT
The present experiments have been performed to assess whether the increased severity of gentamicin-induced nephrotoxicity in old animals could be mediated by a decreased production of nitric oxide. Aging rats (12 months) treated with gentamicin showed higher plasma creatinine and a higher reduction in creatinine clearance. After gentamicin treatment, glomerular nitrite production was higher in young than in old animals, whereas no differences in cortical gentamicin concentration were observed between young and aging animals. The increased severity of gentamicin-induced acute renal failure in old animals could be based on a decreased glomerular NO production after gentamicin treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Espanha