Your browser doesn't support javascript.
loading
From Pauling's abzyme concept to the new era of hydrolytic anti-DNA autoantibodies: a link to rational vaccine design? - A review.
Pavlovic, Mirjana; Cavallo, Michelle; Kats, Anna; Kotlarchyk, Alex; Zhuang, Hanqi; Shoenfeld, Yehuda.
Afiliação
  • Pavlovic M; Department of Computer and Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, Florida 33431, USA. mpavlovi@fau.edu
Int J Bioinform Res Appl ; 7(3): 220-38, 2011.
Article em En | MEDLINE | ID: mdl-21816712
Specific entities of naturally-occurring DNA hydrolytic/cytotoxic antibodies (abzymes) are linked to autoimmune and lymphoproliferative disorders. Suggested sequence of underlying activities conform to such entities penetrating the living cells, trans-locating to nucleus and recognising specific binding sites within single- or double-stranded DNA. Their origin is unknown since corresponding immunogens are unidentified. These anti-DNA antibodies could be the organism's immune response to microbial attack. Their structure, function and pathogenicity were investigated in wet-lab and via bioinformatics in context of Rational Vaccine Designs. This paper offers a comprehensive critical review on the subject in the light of known and newly proposed concepts.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Anticorpos Antinucleares Idioma: En Revista: Int J Bioinform Res Appl Assunto da revista: INFORMATICA MEDICA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Anticorpos Antinucleares Idioma: En Revista: Int J Bioinform Res Appl Assunto da revista: INFORMATICA MEDICA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos