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Fibulin-3 promoter methylation alters the invasive behavior of non-small cell lung cancer cell lines via MMP-7 and MMP-2 regulation.
Kim, Eun Jin; Lee, So Yong; Woo, Mi Kyung; Choi, Soo Im; Kim, Tae Rim; Kim, Min-Jung; Kim, Kug Chan; Cho, Eun Wie; Kim, In Gyu.
Afiliação
  • Kim EJ; Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, 1045 Daedeok-Daero, Yusong-gu, Daejeon 305-353, Republic of Korea.
Int J Oncol ; 40(2): 402-8, 2012 Feb.
Article em En | MEDLINE | ID: mdl-21901248
ABSTRACT
Fibulin-3, an extracellular glycoprotein, has been suggested as having functions in tissue regeneration and organogenesis. However, its role in cancer remains unclear. We show here that fibulin-3 was silenced by hypermethylation of the promoter region in the relatively invasive A549 non-small cell lung cancer (NSCLC) cells compared with less invasive H460 NSCLC cells. Enforced expression of fibulin-3 in A549 cells down-regulated cellular MMP-7 and MMP-2, which was followed by inhibition of cell invasiveness. Conversely, suppression of fibulin-3 expression with siRNA in H460 cells showed the opposite effect. These results indicate that fibulin-3 is a negative regulator of invasiveness in NSCLC and further studies are needed for its therapeutic applications in treatment of NSCLC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Proteínas da Matriz Extracelular / Regiões Promotoras Genéticas / Metilação de DNA / Metaloproteinase 2 da Matriz / Metaloproteinase 7 da Matriz Limite: Humans Idioma: En Revista: Int J Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Proteínas da Matriz Extracelular / Regiões Promotoras Genéticas / Metilação de DNA / Metaloproteinase 2 da Matriz / Metaloproteinase 7 da Matriz Limite: Humans Idioma: En Revista: Int J Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2012 Tipo de documento: Article