Isolation and nucleotide sequence determination of a gene encoding a heat-stable enterotoxin of Escherichia coli.
Toxicon
; 28(4): 453-6, 1990.
Article
em En
| MEDLINE
| ID: mdl-2190361
ABSTRACT
An enterotoxin-producing strain of E. coli has been isolated from an infant patient in Shanghai Children Hospital and the gene of its heat-stable enterotoxin has been cloned and sequenced. The pre-pro-STI was composed of 72 amino acid residues corresponding to the encoding of 216 base pairs. There was only one nucleotide difference in the pro-part between this STI gene and the STIb gene reported in the literature. A guanosine base in our STI gene was substituted for a cytosine base in STIb gene resulting in a replacement of proline by alanine. Hence, the STI genes from different human sources are highly conserved though mutagenesis still occurs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Enterotoxinas
/
Escherichia coli
/
Genes Bacterianos
Limite:
Humans
Idioma:
En
Revista:
Toxicon
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
China