Structure of the human centromere at metaphase.
Trends Biochem Sci
; 15(5): 181-5, 1990 May.
Article
em En
| MEDLINE
| ID: mdl-2193435
ABSTRACT
Until recently the centromere was thought to be a relatively homogeneous region of densely packed heterochromatin with a single differentiated domain--the kinetochore--at its surface, representing the point of attachment of the mitotic spindle. We now know that the centromere of higher eukaryotes is composed of several domains that have been identified using antibody probes. Somewhere within the domains are located both the factor(s) that control the disjunction of sister chromatids and the molecular motor responsible for chromosome movement towards the spindle poles.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Centrômero
/
Cromossomos
/
Metáfase
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
1990
Tipo de documento:
Article