[Alternatively activated macrophages in helminth infections].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
; 29(3): 219-23, 2011 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-21970115
ABSTRACT
Macrophages not only initiate and modulate immune responses, but also are the final effector cells. Recent studies suggested that macrophages conventionally associated with IFN-gamma dominant Th1-type responses and also playing an essential role in the Th2-type inflammatory response, exhibit a quite different activation from the classically activated macrophages (CAM Phi) stimulated during Th1-type responses, therefore named as alternatively activated macrophages (AAM Phi). AAM Phi have multiple effects during helminth infection, including control of inflammatory reaction, contribution to fibrosis and repair at the site of injury, and anti-helminth effect. This article reviews recent findings regarding the role of AAM Phi in the development of disease and host protection following helminth infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Th2
/
Helmintíase
/
Ativação de Macrófagos
/
Macrófagos
Idioma:
Zh
Revista:
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
Assunto da revista:
PARASITOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China