Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia.
Leuk Res
; 36(4): 474-8, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-22071137
ABSTRACT
Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Promielocítica Aguda
Limite:
Adult
/
Aged
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Child
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália