Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas.
J Clin Invest
; 86(4): 1151-7, 1990 Oct.
Article
em En
| MEDLINE
| ID: mdl-2212004
ABSTRACT
An abnormality in the c-sis protooncogene was identified in leukocyte DNA from members of a family predisposed to the development of meningioma, and was found to be associated with the development of the tumor in those individuals. Molecular analysis of this abnormality demonstrated a deletion within the fifth intron of the c-sis gene. The normal c-sis gene has an Alu sequence in this region which includes two perfect 130 nucleotide repeated sequences separated by 5 bp. The deleted c-sis allele is missing precisely one copy of the 130 bp repeat and the intervening 5 bp. An identical deletion was also found in DNA from 1 of 13 sporadic meningiomas.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proto-Oncogenes
/
Fator de Crescimento Derivado de Plaquetas
/
Íntrons
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Sequências Repetitivas de Ácido Nucleico
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Deleção Cromossômica
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Proteínas Proto-Oncogênicas
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Neoplasias Meníngeas
/
Meningioma
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Clin Invest
Ano de publicação:
1990
Tipo de documento:
Article