Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37.
Biochem Biophys Res Commun
; 417(3): 961-5, 2012 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-22202175
ABSTRACT
The herpes simplex virus type 1 (HSV-1) structural tegument protein pUL37, which is conserved across the Herpesviridae family, is known to be essential for secondary envelopment during the egress of viral particles. To shed light on additional roles of pUL37 during viral replication a yeast two-hybrid screen of a human brain cDNA library was undertaken. This screen identified ten host cell proteins as potential pUL37 interactors. One of the interactors, serine threonine kinase TAOK3, was subsequently confirmed to interact with pUL37 using an in vitro pulldown assay. Such host cell/pUL37 interactions provide further insights into the multifunctional role of this herpesviral tegument protein.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Proteínas Estruturais Virais
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Proteínas Serina-Treonina Quinases
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Herpesvirus Humano 1
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Interações Hospedeiro-Patógeno
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Herpes Simples
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Austrália