"Onycholemmal carcinoma." An unusual case with apocrine and sebaceous differentiation. Are these tumors a microcystic nail bed carcinoma?
Am J Dermatopathol
; 34(5): 549-52, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22407068
ABSTRACT
Subungual malignant epithelial tumors with tricholemmal keratinization have rarely been described as "malignant proliferating onycholemmal cyst" and "onycholemmal carcinoma (OC)." We report an additional case of a slow growing OC occurring on the middle finger of a 58-year-old man, which was unusual as it showed sebaceous-apocrine differentiation, in addition to a nail bed carcinoma with tricholemmal microcysts. We therefore consider the descriptive term of microcystic nail bed carcinoma more appropriate than OC. It is recognized that none of the rare cases of OC meet the classical additional criteria proposed by Headington for tricholemmal carcinoma, that is, lobular arrangement, peripheral palisading, thickened basement membrane, and glycogen-positive tumors cells. On the other hand, we suggest that the term follicular microcysts of the nail bed should be retained to describe the true nature of subungual epidermoid inclusions, which show usually a limited differentiation toward the follicular isthmus. Therefore, the previous cases of OC without sebaceous-apocrine differentiation could be best classified as a microcystic nail bed carcinoma arising from the follicular microcysts of the nail bed, with a limited differentiation toward the keratinization of the follicular isthmus.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândulas Apócrinas
/
Glândulas Sebáceas
/
Neoplasias Cutâneas
/
Carcinoma
/
Diferenciação Celular
/
Doenças da Unha
/
Unhas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Dermatopathol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França