[A case of neonatal lupus syndrome and congenital atrioventricular block associated with maternal antibodies antiRo/SS-A]. / Un caso di lups neonatale con blocco atrioventricolare congenito da madre con anticorpi antiRo/SS-A.
Minerva Pediatr
; 64(2): 251-6, 2012 Apr.
Article
em It
| MEDLINE
| ID: mdl-22495199
ABSTRACT
The neonatal lupus erythematosus syndrome (LEN) is a disease due to the transplacental passage of maternal antiextractable nuclear antigens (ENA) antibodies, particularly anti-Ro/SS-A and anti-La/SS-B. The disease affects neonates born from mothers with autoimmune diseases. It is characterized by erythematous annular polycylic skin lesions, slightly scaling with prevalent face localization, hematologic and liver diseases and only in 2% of cases with extracutaneous lesions including complete atrioventricular block. The Authors describe a case of LEN characterized by isolated atrioventricular block at birth and endocardial fibroelastosis without skin lesions in a preterm infant female. She was born from asymptomatic, ANA (Anti-Nuclear Antibodies) and ENA (anti-Extractable Nuclear Antigen) positive mother, with a previous miscarriage at the 5th week of gestation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Antinucleares
/
Bloqueio Atrioventricular
/
Doenças do Prematuro
/
Lúpus Eritematoso Sistêmico
/
Troca Materno-Fetal
/
Mães
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
It
Revista:
Minerva Pediatr
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália