Your browser doesn't support javascript.
loading
Evaluation of MDM2, p16, and p53 staining levels as biomarkers of biochemical recurrence following salvage radiation therapy for recurrent prostate cancer.
Heckman, Michael G; Parker, Alexander S; Wu, Kevin J; Hilton, Tracy W; Ko, Stephen J; Pisansky, Thomas M; Schild, Steven E; Khor, Li Yan; Hammond, Elizabeth H; Pollack, Alan; Buskirk, Steven J.
Afiliação
  • Heckman MG; Biostatistics Unit, Mayo Clinic Florida, Jacksonville, Florida 32224, USA. heckman.michael@mayo.edu
Prostate ; 72(16): 1757-66, 2012 Dec 01.
Article em En | MEDLINE | ID: mdl-22513981
BACKGROUND AND PURPOSE: The selection of appropriate candidates for salvage radiation therapy (SRT) to address a rising PSA following radical prostatectomy remains challenging. Herein, we provide the first evaluation of the ability of staining levels of the tumor based biomarkers MDM2, p16, and p53 to aid in prediction of biochemical recurrence (BCR) among men undergoing SRT for recurrent prostate cancer. MATERIAL AND METHODS: We identified 152 patients who were treated with SRT between July 1987 and July 2003. Staining levels of MDM2, p16, and p53 in primary tumor samples removed during prostatectomy were detected using monoclonal antibodies and quantified by use of a computer-assisted method. Associations of staining levels with BCR were evaluated using Cox proportional hazards regression models; relative risks (RRs) and 95% confidence intervals (CIs) were estimated. RESULTS: Compared to patients with low staining (≤median) as measured by percentage of cells with nuclear staining, there was no significant difference in risk of BCR for patients with high MDM2 staining (RR: 0.90, 95% CI: 0.57-1.45, P = 0.67), high p16 staining (RR: 0.88, 95% CI: 0.54-1.44, P = 0.62), or high p53 staining (RR: 1.33, 95% CI: 0.84-2.11, P = 0.23) in multivariable analysis. These results were consistent when considering alternate percentile cutpoints and alternate quantifications of biomarker staining. CONCLUSIONS: Our results provide evidence that MDM2, p16, and p53 staining levels are not useful in the prediction of BCR after SRT. As such, these biomarkers are of little clinical use in the selection of appropriate candidates for SRT.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Proteínas de Neoplasias / Recidiva Local de Neoplasia Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Prostate Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Proteínas de Neoplasias / Recidiva Local de Neoplasia Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Prostate Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos