BRAT-BW: efficient and accurate mapping of bisulfite-treated reads.
Bioinformatics
; 28(13): 1795-6, 2012 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-22563065
ABSTRACT
SUMMARY:
We introduce BRAT-BW, a fast, accurate and memory-efficient tool that maps bisulfite-treated short reads (BS-seq) to a reference genome using the FM-index (Burrows-Wheeler transform). BRAT-BW is significantly more memory efficient and faster on longer reads than current state-of-the-art tools for BS-seq data, without compromising on accuracy. BRAT-BW is a part of a software suite for genome-wide single base-resolution methylation data analysis that supports single and paired-end reads and includes a tool for estimation of methylation level at each cytosine.AVAILABILITY:
The software is available in the public domain at http//compbio.cs.ucr.edu/brat/.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfitos
/
Software
/
Análise de Sequência de DNA
/
Metilação de DNA
/
Sequenciamento de Nucleotídeos em Larga Escala
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos