Mannose receptor may be involved in small ruminant lentivirus pathogenesis.
Vet Res
; 43: 43, 2012 May 16.
Article
em En
| MEDLINE
| ID: mdl-22591485
Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n = 3), seronegative (n = 3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n = 1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Ovinos
/
Regulação da Expressão Gênica
/
Infecções por Lentivirus
/
Provírus
/
Lentivirus Ovinos-Caprinos
/
Receptores de Superfície Celular
/
Carga Viral
/
Lectinas Tipo C
/
Lectinas de Ligação a Manose
Tipo de estudo:
Etiology_studies
Limite:
Animals
País/Região como assunto:
Europa
Idioma:
En
Revista:
Vet Res
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Espanha