Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease.
Curr Opin Clin Nutr Metab Care
; 15(4): 374-80, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22617564
ABSTRACT
PURPOSE OF REVIEW Obesity-associated nonalcoholic fatty liver disease (NAFLD) is highly prevalent, for which weight loss is the generally recommended clinical management. Low-carbohydrate ketogenic diets have been successful in promoting weight loss, but variations in the range of metabolic responses to these diets indicate that the effects of altering macronutrient content are not completely understood. This review focuses on the most recent findings that reveal the relationship between low-carbohydrate diets and NAFLD in rodent models and humans. RECENT FINDINGS:
Low-carbohydrate diets have been shown to promote weight loss, decrease intrahepatic triglyceride content, and improve metabolic parameters of patients with obesity. These ketogenic diets also provoke weight loss in rodents. However, long-term maintenance on a ketogenic diet stimulates the development of NAFLD and systemic glucose intolerance in mice. The relationship between ketogenic diets and systemic insulin resistance in both humans and rodents remains to be elucidated.SUMMARY:
Because low-carbohydrate ketogenic diets are increasingly employed for treatment of obesity, NAFLD, and neurological diseases such as epilepsy, understanding the long-term systemic effects of low-carbohydrate diets is crucial to the development of efficacious and safe dietary interventions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Redução de Peso
/
Intolerância à Glucose
/
Dieta Redutora
/
Dieta com Restrição de Carboidratos
/
Dieta Cetogênica
/
Fígado Gorduroso
/
Obesidade
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Clin Nutr Metab Care
Assunto da revista:
CIENCIAS DA NUTRICAO
/
METABOLISMO
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos