Cloning of canine gastrin cDNA's encoding variant amino acid sequences.
Digestion
; 46 Suppl 2: 99-104, 1990.
Article
em En
| MEDLINE
| ID: mdl-2262079
ABSTRACT
We have isolated 2 clones encoding gastrin from a canine antral mucosa cDNA library. The clones differed in nucleotide sequence at 2 sites in the coding region. One of the clones confirmed the amino acid sequence of dog gastrin obtained by peptide purification and analysis. An A-G substitution in the other clone resulted in a Thr-Ala substitution in the region encoding the biologically active carboxyl-terminal portion of gastrin. The source of the observed heterogeneity in cDNA sequences is not known but its location may have implications with regard to the physiology of gastrin in dogs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Gastrinas
Limite:
Animals
Idioma:
En
Revista:
Digestion
Ano de publicação:
1990
Tipo de documento:
Article