[Subpopulation structure of T-regulatory cells and proliferative response of blood lymphocytes in vitro under pulmonary tuberculosis].
Patol Fiziol Eksp Ter
; (1): 13-8, 2012.
Article
em Ru
| MEDLINE
| ID: mdl-22629854
ABSTRACT
Subpopulation structure of T-regulatory cells and proliferative activity of blood lymphocytes in vitro in patients with different clinical forms of pulmonary tuberculosis were studied in this work. It has been shown that Trn--natural T-regulatory lymphocytes (CD4+CD25+Foxp3+) play a leading role in formation of immune suppression under infiltrative, disseminated and fibrosis-cavernous pulmonary tuberculosis. Besides, their number is increased in blood of both tuberculin-positive and tuberculin-negative patients. Negative correlation between the number of Trn and proliferative activity of blood lymphocytes (basal, mitogen- and antigen-induced)has been established, which testifies about participation of Trn in suppression of lymphocyte proliferation and Th1- and Th2-immune response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Subpopulações de Linfócitos T
/
Linfócitos T Reguladores
/
Proliferação de Células
/
Tolerância Imunológica
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Patol Fiziol Eksp Ter
Ano de publicação:
2012
Tipo de documento:
Article