The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression.
Wiley Interdiscip Rev RNA
; 3(5): 675-95, 2012.
Article
em En
| MEDLINE
| ID: mdl-22777840
ABSTRACT
The human mitochondrial transcriptome, although produced from a small and compact genome, has revealed surprising complexity in its composition and regulation. Wide variation between individual tRNAs, mRNAs, and rRNAs indicate the importance of post-transcriptional processing, maturation, and degradation mechanisms in the regulation of mitochondrial gene expression. RNA-binding proteins play essential roles in controlling the mitochondrial transcriptome from its synthesis to its destruction and have evolved unique features to complement the unusual features of mitochondrial RNAs. Recent studies have shown how changes in mitochondrial RNAs and their binding proteins can have significant effects on human health. This opens new avenues for investigation of mitochondrial RNA-binding proteins and the mechanisms by which they regulate mitochondrial gene expression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
/
Proteínas de Ligação a RNA
/
Transcriptoma
/
Mitocôndrias
Limite:
Humans
Idioma:
En
Revista:
Wiley Interdiscip Rev RNA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Austrália