[Efficacy and safety of tandospirone in the treatment of patients with anxiety disorder].
Zhonghua Yi Xue Za Zhi
; 92(13): 920-3, 2012 Apr 03.
Article
em Zh
| MEDLINE
| ID: mdl-22781535
ABSTRACT
OBJECTIVE:
To explore the efficacy and safety of tandospirone for adolescents with anxiety disorder.METHODS:
In this multicenter open-label 12-week study, a total of 169 adolescents met the criteria of DSM-IV for anxiety disorder were treated with flexible dose of tandospirone. The effects and safety of treatment were assessed by the Hamilton anxiety scale (HAMA), state-trait anxiety inventory (STAI), clinical global impression (CGI) and side effects at baseline and Weeks 2, 4, 8 and 12.RESULTS:
In 151 cases completing the 12-week treatment, the scores of HAMA decreased by 18% ± 12%, 38% ± 16%, 54% ± 20% and 63% ± 17% at Weeks 2, 4, 8 and 12. Significant reductions in HAMA scores were seen at Weeks 2-12 (P < 0.01) and marked improvement appeared in 81.5% cases at Week 12 (reduction rate of HAMA 50%). At Week 12, the HAMD(17) scores were markedly lower versus baseline (7 ± 2 vs 13 ± 3, P < 0.01). Adverse effect of tandospirone was scarcely found (9.9%).CONCLUSION:
Tandospirone is an effective and safe anti-anxiety drug for adolescents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Ansiedade
/
Piperazinas
/
Pirimidinas
/
Ansiolíticos
/
Isoindóis
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China