Infection with HIV as a risk factor for adverse obstetrical outcome.
AIDS
; 4(11): 1087-93, 1990 Nov.
Article
em En
| MEDLINE
| ID: mdl-2282181
ABSTRACT
We carried out a case-control study to investigate the role of sexually transmitted diseases (STDs), including infection with HIV, as risk factors for adverse outcome of pregnancy. Overall, 1507 women were enrolled within 24 h of delivery. Cases (n = 796) were mothers of low-birthweight infants (less than 2500 g) or of stillborns. Low-birthweight infants were divided into preterms (n = 373) and neonates small for gestational age (n = 234). Stillborns were separated into intrauterine fetal deaths (n = 120), and intrapartum fetal deaths (n = 69). Controls were selected from mothers delivering a live baby of greater than or equal to 2500 g (n = 711). The maternal HIV seroprevalence in the control group was 3.1%. Prematurity was associated with maternal HIV antibody [8.6% seropositive; adjusted odds ratio (OR) 2.1; 95% confidence interval (CI) 1.1-4.0], as was being born small for gestational age (7.7% seropositive; adjusted OR 2.3; 95% CI 1.2-4.2). In mothers who delivered a stillborn baby, both intrauterine fetal death (11.7% seropositive; adjusted OR 2.7; 95% CI 1.3-5.5) and intrapartum fetal death (11.6% seropositive; adjusted OR 2.9; 95% CI 1.3-6.5) were independently associated with HIV seropositivity in the mother. Maternal syphilis was confirmed as an important risk factor for intrauterine fetal death (14.3% positive; adjusted OR 4.8; 95% CI 2.4-9.5). No significant association was found between other STDs, including gonococcal and chlamydial infection, and adverse obstetrical outcome. These results suggest an association between maternal HIV infection and adverse obstetrical outcome, defined as low birthweight and stillbirth.
Palavras-chave
Africa; Africa South Of The Sahara; Age Factors; Behavior; Biology; Birth Weight; Body Weight; Case Histories; Control Groups; Data Analysis; Data Collection; Demographic Factors; Developing Countries; Diseases; Eastern Africa; English Speaking Africa; Examinations And Diagnoses; Fertility; Fertility Measurements; Fetal Death; Hiv Infections; Infections; Kenya; Laboratory Examinations And Diagnoses; Low Birth Weight; Mortality; Parity; Physiology; Population; Population Characteristics; Population Dynamics; Pregnancy; Pregnancy History; Pregnancy Outcomes; Reproduction; Reproductive Tract Infections; Research Methodology; Risk Factors; Sex Behavior; Sexually Transmitted Diseases; Viral Diseases
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Resultado da Gravidez
/
Infecções por HIV
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Quênia