Does higher NORs expression affect the developmental stages of Down syndrome infants?
Genet Couns
; 23(2): 249-53, 2012.
Article
em En
| MEDLINE
| ID: mdl-22876584
ABSTRACT
BACKGROUND:
The nucleolar organizer regions (NORs) are localized at the secondary constriction of the five pairs of acrocentric chromosomes (13, 14, 15, 21 and 22) in human. MATERIALS ANDMETHODS:
To evaluate whether increasing AgNOR protein synthesis effects or not the development of babies/children, 25 Down syndrome patients were included in this study. Firstly, the Ankara Development Screening Inventory (AGTE) test was performed. Then the buccal epithelial cells of patients were taken via a sterile toothpick on clean glass slides and spreaded and AgNOR staining technique was applied to the slides of each individual. Mean NOR area/Total nucleus area (NORa/TNa) were evaluated for each nucleus using a special computer program.RESULTS:
The mean NORa/TNa was found to be 3.8+/-1.16. According to these data, a significant correlation was not evident between the NORa/TNa and developmental stages (p>0.05).CONCLUSIONS:
There is no correlation between extra energy spending for NOR protein synthesis and developmental deficiency.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Desenvolvimento Infantil
/
Síndrome de Down
/
Antígenos Nucleares
/
Região Organizadora do Nucléolo
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Genet Couns
Assunto da revista:
ETICA
/
GENETICA MEDICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Turquia