[Diffusion tensor imaging analyses of white matter at an early stage of first-episode schizophrenia].
Zhonghua Yi Xue Za Zhi
; 92(19): 1307-9, 2012 May 22.
Article
em Zh
| MEDLINE
| ID: mdl-22883115
ABSTRACT
OBJECTIVE:
To explore the roles of diffusion tensor imaging (DTI) of white matter at an early stage of schizophrenia.METHODS:
The participants were 20 first-episode, medication-naïve schizophrenics at an early stage (1 - 6 months) and 20 healthy controls adjusted in gender and age during December 2009 and October 2010. They underwent diffusion weighted magnetic resonance imaging with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups underwent two-sample paired t-test with SPM5 software.RESULTS:
The schizophrenics at an early stage demonstrated a significant decrease of regional white matter FA values in right anterior cingulated (MNI x = 12, y = 24, z = -10; cluster = 145) and right middle occipital lobe (MNI x = 36, y = -76, z = -2; cluster = 135).CONCLUSION:
The altered white matter DTI in right anterior cingulated and middle occipital lobe may contribute to an early detection of schizophrenia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Imagem de Tensor de Difusão
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China