Synthesis and structure of two new mycolactones isolated from M. ulcerans subsp. shinshuense.
Org Lett
; 14(17): 4618-21, 2012 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-22924773
ABSTRACT
Two new mycolactones, mycolactones S1 and S2, were isolated from culture agar of Mycobacterium ulcerans subsp. shinshuense. Their structures were established in a three-step procedure (1) probable structures were speculated from MS analysis; (2) candidates were synthesized; (3) HPLC profiles were established for identification of the natural products. Newly isolated mycolactones correspond to the "oxidized forms" of mycolactone A/B, the causative toxin of Buruli ulcer, isolated from Mycobacterium ulcerans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
/
Mycobacterium ulcerans
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos