Effects of autologous, cross-linked erythrocytes on isolated hypoperfused rabbit heart dynamics.
Pharmacology
; 90(5-6): 274-80, 2012.
Article
em En
| MEDLINE
| ID: mdl-23038665
ABSTRACT
The present study was aimed at assessing the effects of either red blood cells (RBC) or RBC cross-linked with the bifunctional dimethyl suberimidate reagent (C-RBC) on contractile force (CFo), heart rate (HR) and coronary flow (CF) of the isolated rabbit heart hypoperfused with RBC suspensions under 30 mm Hg constant pressure. RBC or C-RBC caused a rapid and marked reduction of CF, CFo and HR. In RBC-treated hearts, however, reperfusion with Tyrode solution partially restored the initial myocardial parameters, while in C-RBC-treated hearts a rapid impairment of diastolic relaxation with a subsequent, steady and increasing heart contracture was observed. Histological analysis showed that in C-RBC-perfused hearts either capillaries or precapillary arterioles were occluded by C-RBC in spite of extensive washings with Tyrode solution. These findings indicate that C-RBC impair coronary circulation markedly and irreversibly.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reagentes de Ligações Cruzadas
/
Dimetil Suberimidato
/
Eritrócitos
/
Coração
Limite:
Animals
Idioma:
En
Revista:
Pharmacology
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália