Autophagy and toxins: a matter of life or death.
Curr Mol Med
; 13(2): 241-51, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23228127
ABSTRACT
Bacterial protein toxins are important virulence factors. A particular class of toxins, the pore-form toxins (PFTs), shares the toxigenic mechanism of forming pores in the membrane of target cells. The relationship between autophagy and bacterial PFTs has been described for several toxin-secreting pathogens and in this review we have recapitulated the more recent findings on this issue. A common outcome is that the target cell, by a yet non-completely defined mechanism, senses the toxin attack and builds up complex responses as a protective mechanism for host survival. However, in some cases, this cellular response is beneficial to the microorganism by supplying an intracellular niche or by promoting host-cell death, which facilitates pathogen spreading.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Toxinas Bacterianas
/
Fatores de Virulência
/
Proteínas Citotóxicas Formadoras de Poros
/
Bactérias Gram-Negativas
/
Bactérias Gram-Positivas
Limite:
Humans
Idioma:
En
Revista:
Curr Mol Med
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Argentina