Association of single nucleotide polymorphisms of interleukin-1 family with atopic dermatitis.
Allergol Immunopathol (Madr)
; 42(3): 212-5, 2014.
Article
em En
| MEDLINE
| ID: mdl-23253688
ABSTRACT
BACKGROUND:
Interleukin-1 (IL-1) seems to have an important role in early reactions towards microbes, while its genetic variability could affect this role in atopic patients who have a distressed immunity towards dermatological infections.METHODS:
Eighty-nine patients with atopic dermatitis (AD), who were referred to a main referral paediatric hospital, were enrolled in this study. Single nucleotide polymorphisms (SNP) of the following IL-1 cluster genes were assessed in this group of patients IL-1α -889, IL-1ß -511, IL-1ß +3962, IL-1R Pst-I 1970, and IL-1RA Mspa-I 11100. The results were compared with a group of 140 healthy subjects from the same region.RESULTS:
Fourteen percent of the controls had TT homozygous genotype in IL-1R at position Pst-I 1970, while only 2% of the patients with AD had this genotype (p=0.005, OR 0.14, 95%CI 0.02-0.64). The CC homozygous genotype was the most common genotype in IL-1α position -889 and IL-1ß at position +3962 in both groups of patients with AD and the controls, while the TC heterozygous genotype was the most common genotype in IL-1ß at position -511 and IL-1R at position Pst-I 1970, with no significant difference between the two groups.CONCLUSIONS:
This study showed a significant negative association in the IL-1R Mspa-I 11100 TT homozygous genotype in the patients with AD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dermatite Atópica
/
Proteína Antagonista do Receptor de Interleucina 1
/
Interleucina-1alfa
/
Interleucina-1beta
Tipo de estudo:
Risk_factors_studies
Limite:
Child
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Allergol Immunopathol (Madr)
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Irã