False negative results in axillary lymph nodes by ultrasonography and ultrasonography-guided fine-needle aspiration in patients with invasive ductal carcinoma.
Ultraschall Med
; 34(6): 559-67, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23258771
ABSTRACT
PURPOSE:
For preoperative evaluation of ALN status using various methods, axillary US and subsequent US-FNA targeting the LNs suspicious for metastasis are the most widely used methods. The purpose of our study was to assess the rate of false-negative results at preoperative ultrasonography (US) and ultrasonography guided fine needle aspiration (US-FNA) of axillary lymph nodes (ALNs) in breast cancer patients and the number of false-negative lymph nodes, and to evaluate factors related to ALN false negative results in US and/or US-FNA in patients diagnosed with invasive ductal carcinoma. MATERIALS ANDMETHODS:
Among 317 patients who underwent surgery for invasive ductal carcinoma during 2009 in Severance hospital, 237 patients had no reported ALN metastasis on preoperative US-FNA and US.âWe retrospectively reviewed the subsequent surgical pathology and clinicopathologic findings and assessed the rate of false-negative results from US and US-FNA of ALN and the number of false-negative lymph node. We performed univariate analysis and multivariate logistic regression analysis to evaluate the relationships between variable clinicopathologic factors (T-stage, position of ALN, hormone receptors, histologic grade, lymphovascular invasion (LVI) and performance of FNA) and cytologic results (false-negative result; FNALN and true negative result; TNALN) from US and/or US-FNA of ALN.RESULTS:
The rate of false-negative results was 42.4â% (59/139) in both US and US-FNA of ALN but among them, 57.6â% (34/59) showed only one metastatic ALN. Breast cancer with FNALN on US and US-FNA was significantly related to positive estrogen receptor (pâ=â0.003), positive progesterone receptor (pâ=â0.001), and the presence of LVI (pâ=â0.004) in univariate analysis. In multivariate analysis, high T stages (≥âT2, odds ratio (OR) 4.007, pâ=â0.004) and LVI (OR 7.951, pâ=â0.001) showed significant correlation with FNALN on US and US-FNA.CONCLUSION:
More than half of patients with FNALN showed only one metastatic ALN. LVI and high T-stages were the most important factors attributed to FNALN on US and US-FNA in patients with invasive ductal carcinoma.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Ultrassonografia de Intervenção
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Carcinoma Ductal de Mama
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Biópsia por Agulha Fina
/
Linfonodos
/
Metástase Linfática
Tipo de estudo:
Observational_studies
Limite:
Adult
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Aged
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Female
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Humans
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Infant
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Middle aged
Idioma:
En
Revista:
Ultraschall Med
Ano de publicação:
2013
Tipo de documento:
Article