Cardiac autonomic function and insulin resistance for the development of hypertension: a six-year epidemiological follow-up study.
Nutr Metab Cardiovasc Dis
; 23(12): 1216-22, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23419733
ABSTRACT
BACKGROUND AND AIMS:
To explore the impact of cardiac autonomic function (CAF) and insulin resistance (IR) on incident hypertension. METHODS ANDRESULTS:
In 1996, 1638 subjects finished baseline examination, which included anthropometry, blood pressures, CAF, blood biochemistry, plasma insulin, urine examination and electrocardiogram. CAF included standard deviation of normal-to-normal intervals or RR intervals (SDNN), low- and high-frequency power spectrum (LF and HF), and LF/HF ratio at supine for 5 min, the RR interval changes during lying-to-standing maneuver, and the ratio between the longest RR interval during expiration and the shortest RR interval during inspiration (E/I ratio). We used homeostasis model assessment to define beta cell function (HOMA-B) and insulin resistance (HOMA-IR). In total, 992 non-hypertensive participants completed the follow-up assessment in 2003 and 959 participants were included for the final analysis. Incident hypertension was determined by blood pressure status at follow-up. In unadjusted model, both square root of HOMA-IR (OR3.37, 95%CI 2.10-6.64) and HOMA-B (OR0.996, 95%CI 0.992-0.999) were related to incident hypertension. In multivariate model, square root of HOMA-IR (OR1.97, 95%CI 1.05-3.70), but not HOMA-B, was associated with incident hypertension. After further adjustment for baseline CAF, the positive relationship between the square root of HOMA-IR and incident hypertension disappeared. In contrast, LF/HF ratio (OR1.18, 95%CI 1.01-1.37), HF power (OR0.98, 95%CI 0.96-0.999), and E/I ratio (OR0.71, 95%CI 0.54-0.95) were each independently associated with incident hypertension after further adjustment for HOMA measures.CONCLUSION:
Sympathovagal imbalance with an apparently decreased parasympathetic tone is an important predictor of incident hypertension independent of IR.Palavras-chave
30max/15min ratio; CAF; Cardiac autonomic function; E/I ratio; HF; HOMA-B; HOMA-IR; IR; Incident hypertension; Insulin resistance; LF; SDNN; a ratio between the RR intervals during expiration and inspiration; a ratio between the longest RR interval around the 30th beat and the shortest RR interval around the 15th beat after standing; cardiac autonomic function; high frequency; homeostasis model assessment for insulin resistance; homeostasis model assessment to define beta cell function; insulin resistance; low frequency; standard deviation of normal-to-normal intervals or RR intervals
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Parassimpático
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Resistência à Insulina
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Coração
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Hipertensão
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
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CIENCIAS DA NUTRICAO
/
METABOLISMO
Ano de publicação:
2013
Tipo de documento:
Article