The pup-proteasome system of Mycobacterium tuberculosis.
Subcell Biochem
; 66: 267-95, 2013.
Article
em En
| MEDLINE
| ID: mdl-23479444
ABSTRACT
Proteasomes are ATP-dependent protein degradation machines present in all archaea and eukaryotes, and found in several bacterial species of the order Actinomycetales. Mycobacterium tuberculosis (Mtb), an Actinomycete pathogenic to humans, requires proteasome function to cause disease. In this chapter, we describe what is currently understood about the biochemistry of the Mtb proteasome and its role in virulence. The characterization of the Mtb proteasome has led to the discovery that proteins can be targeted for degradation by a small protein modifier in bacteria as they are in eukaryotes. Furthermore, the understanding of proteasome function in Mtb has helped reveal new insight into how the host battles infections.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Ubiquitinas
/
Processamento de Proteína Pós-Traducional
/
Complexo de Endopeptidases do Proteassoma
/
Mycobacterium tuberculosis
Idioma:
En
Revista:
Subcell Biochem
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos