The new revolution in toxicology: the good, the bad, and the ugly.
Ann N Y Acad Sci
; 1278: 11-24, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23488558
ABSTRACT
In 2007, the United States National Academy of Sciences issued a report entitled Toxicity Testing in the 21(st) Century A Vision and a Strategy. The report reviewed the state of the science and outlined a strategy for the future of toxicity testing. One of the more significant components of the vision established by the report was an emphasis on toxicity testing in human rather than animal systems. In the context of drug development, it is critical that the tools used to accomplish this strategy are maximally capable of evaluating human risk. Since 2007, many advances toward implementation of this vision have been achieved, particularly with regard to safety assessment of new chemical entities intended for pharmaceutical use.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxicologia
/
Testes de Toxicidade
/
Biomarcadores Farmacológicos
/
Descoberta de Drogas
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos