Urinary excretion of porphyrins is increased in patients with HIV-1 infection.
AIDS
; 4(4): 341-4, 1990 Apr.
Article
em En
| MEDLINE
| ID: mdl-2350454
ABSTRACT
Urine concentrations of total porphyrins and of porphyrin precursors, delta-aminolaevulinic acid and porphobilinogen, were analysed in the first-morning urine samples of 36 people with established HIV-1 infection. For comparison, we also analysed the urine samples of 26 healthy HIV-seronegative people. In patients with HIV-1 infection concentrations of total porphyrins were found to be significantly higher than in healthy controls. Furthermore, there was a close correlation between concentrations of total porphyrins and porphobilinogen and urine neopterin concentrations in patients. Our data indicate an association between chronic immune activation and altered porphyrin metabolism. The data may provide a rationale for the observation of acute porphyria in patients with HIV-1 infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfobilinogênio
/
Porfirinas
/
Síndrome da Imunodeficiência Adquirida
/
Ácido Aminolevulínico
/
Ácidos Levulínicos
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Áustria