SLC6 transporters: structure, function, regulation, disease association and therapeutics.
Mol Aspects Med
; 34(2-3): 197-219, 2013.
Article
em En
| MEDLINE
| ID: mdl-23506866
ABSTRACT
The SLC6 family of secondary active transporters are integral membrane solute carrier proteins characterized by the Na(+)-dependent translocation of small amino acid or amino acid-like substrates. SLC6 transporters, which include the serotonin, dopamine, norepinephrine, GABA, taurine, creatine, as well as amino acid transporters, are associated with a number of human diseases and disorders making this family a critical target for therapeutic development. In addition, several members of this family are directly involved in the action of drugs of abuse such as cocaine, amphetamines, and ecstasy. Recent advances providing structural insight into this family have vastly accelerated our ability to study these proteins and their involvement in complex biological processes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Conformação Proteica
/
Sódio
/
Modelos Moleculares
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Família Multigênica
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Sistemas de Transporte de Aminoácidos Neutros
/
Proteínas da Membrana Plasmática de Transporte de Neurotransmissores
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Mol Aspects Med
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos