Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review.
J R Soc Interface
; 10(83): 20121004, 2013 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-23536538
ABSTRACT
Aortic disease is a significant cause of death in developed countries. The most common forms of aortic disease are aneurysm, dissection, atherosclerotic occlusion and ageing-induced stiffening. The microstructure of the aortic tissue has been studied with great interest, because alteration of the quantity and/or architecture of the connective fibres (elastin and collagen) within the aortic wall, which directly imparts elasticity and strength, can lead to the mechanical and functional changes associated with these conditions. This review article summarizes the state of the art with respect to characterization of connective fibre microstructure in the wall of the human aorta in ageing and disease, with emphasis on the ascending thoracic aorta and abdominal aorta where the most common forms of aortic disease tend to occur.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta
/
Doenças da Aorta
/
Envelhecimento
/
Colágeno
/
Elastina
Limite:
Humans
Idioma:
En
Revista:
J R Soc Interface
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos