Leukoaraiosis in asymptomatic adult offspring of individuals with Alzheimer's disease.
Biol Psychiatry
; 27(11): 1244-8, 1990 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-2354229
ABSTRACT
The presence of white matter changes on magnetic resonance imaging (MRI), which has been referred to by Hachinski (1987) as leukoaraiosis, is frequently noted in elderly individuals in conditions ranging from health to frank dementia. This study involved the use of MRI to document cerebral structure if 41 healthy 50-60-year-old individuals, 28 of whom were offspring of Alzheimer's disease victims. On visual inspection of spin-echo images, 13 of the 28 offspring showed white matter lesions whereas all of the controls were free of leukoaraiosis. This statistically significant difference suggests that the presence of leukoaraiosis might be of importance in understanding changes in the white matter among populations at increased risk for Alzheimer's disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Dano Encefálico Crônico
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Imageamento por Ressonância Magnética
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Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
1990
Tipo de documento:
Article