Channelopathies from mutations in the cardiac sodium channel protein complex.
J Mol Cell Cardiol
; 61: 34-43, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23557754
ABSTRACT
The cardiac sodium current underlies excitability in heart, and inherited abnormalities of the proteins regulating and conducting this current cause inherited arrhythmia syndromes. This review focuses on inherited mutations in non-pore forming proteins of sodium channel complexes that cause cardiac arrhythmia, and the deduced mechanisms by which they affect function and dysfunction of the cardiac sodium current. Defining the structure and function of these complexes and how they are regulated will contribute to understanding the possible roles for this complex in normal and abnormal physiology and homeostasis. This article is part of a Special Issue entitled "Na(+) Regulation in Cardiac Myocytes".
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mutação de Sentido Incorreto
/
Canalopatias
/
Canal de Sódio Disparado por Voltagem NAV1.5
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Cell Cardiol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos