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Thalamic control of neocortical area formation in mice.
Vue, Tou Yia; Lee, Melody; Tan, Yew Ei; Werkhoven, Zachary; Wang, Lynn; Nakagawa, Yasushi.
Afiliação
  • Vue TY; Department of Neuroscience, Developmental Biology Center, Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA.
J Neurosci ; 33(19): 8442-53, 2013 May 08.
Article em En | MEDLINE | ID: mdl-23658181
The mammalian neocortex undergoes dramatic transformation during development, from a seemingly homogenous sheet of neuroepithelial cells into a complex structure that is tangentially divided into discrete areas. This process is thought to be controlled by a combination of intrinsic patterning mechanisms within the cortex and afferent axonal projections from the thalamus. However, roles of thalamic afferents in the formation of areas are still poorly understood. In this study, we show that genetically increasing or decreasing the size of the lateral geniculate nucleus of the mouse thalamus resulted in a corresponding change in the size of the primary visual area. Furthermore, elimination of most thalamocortical projections from the outset of their development resulted in altered areal gene expression patterns, particularly in the primary visual and somatosensory areas, where they lost sharp boundaries with adjacent areas. Together, these results demonstrate the critical roles of thalamic afferents in the establishment of neocortical areas.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tálamo / Regulação da Expressão Gênica no Desenvolvimento / Neocórtex Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tálamo / Regulação da Expressão Gênica no Desenvolvimento / Neocórtex Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos