Adsorptive stripping voltammetry determination of methyldopa on the surface of a carboxylated multiwall carbon nanotubes modified glassy carbon electrode in biological and pharmaceutical samples.
Colloids Surf B Biointerfaces
; 109: 253-8, 2013 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-23665091
ABSTRACT
In the present work, a simple carboxylated multiwall carbon nanotubes (CMWCNTs) modified glassy carbon electrode was developed for sensitive determination of methyldopa (MTD). The study of modified electrode and MTD electrochemical behavior at its surface was investigated employing SEM, adsorptive stripping voltammetry, electrochemical impedance spectroscopy and chronocoulometry. These studies show that the oxidation of MTD is facilitated at the surface of GCE which is casted with CMWCNTs and remarkably peak current enhanced comparing to the bare electrode due to its adsorption on the electrode surface. Also, because of the catalytic property of modified electrode onset potential decreased for oxidation of MTD. Under optimized conditions, the calibration curve was linear in two concentration ranges of 0.1-30 and 30.0-300.0 µM with a detection limit of 0.08 µM and relative standard deviation (R.S.D.%) lower than 3.0% (n=5). This modified electrode was used as a sensor for determination of MTD in pharmaceutical and human urine samples with satisfactory results.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbono
/
Ácidos Carboxílicos
/
Nanotubos de Carbono
/
Técnicas Eletroquímicas
/
Metildopa
Limite:
Humans
Idioma:
En
Revista:
Colloids Surf B Biointerfaces
Assunto da revista:
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article