Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.
Pharmacol Res
; 74: 56-67, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23732704
Palavras-chave
2-(4-morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride; 4'-hydroxy-3'-methoxyacetophenone; BD1047; CCI; Chronic constriction injury; N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide; N-acetyl-l-cysteine; N-methyl-D-aspartate; NAC; NADPH oxidase; NADPH oxidase 2; NMDA; Neuropathic pain; PRE084; PWF; PWL; ROS; Reactive Oxygen Species; Sig-1Rs; Sigma-1 receptor; Sigma-1 receptors; apocynin; chronic constriction injury; nicotinamide adenine dinucleotide phosphate oxidase; pNR1; paw withdrawal frequency; paw withdrawal latency; phosphorylation of the NMDA receptor NR1 subunit; reactive oxygen species
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Receptores sigma
/
NADPH Oxidases
/
Hiperalgesia
/
Neuralgia
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Res
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Coréia do Sul