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The influence of combined cognitive plus social-cognitive training on amygdala response during face emotion recognition in schizophrenia.
Hooker, Christine I; Bruce, Lori; Fisher, Melissa; Verosky, Sara C; Miyakawa, Asako; D'Esposito, Mark; Vinogradov, Sophia.
Afiliação
  • Hooker CI; Department of Psychology, Harvard University, 33 Kirkland St., Cambridge, MA 02138, United States. chooker@wjh.harvard.edu
Psychiatry Res ; 213(2): 99-107, 2013 Aug 30.
Article em En | MEDLINE | ID: mdl-23746615
ABSTRACT
Both cognitive and social-cognitive deficits impact functional outcome in schizophrenia. Cognitive remediation studies indicate that targeted cognitive and/or social-cognitive training improves behavioral performance on trained skills. However, the neural effects of training in schizophrenia and their relation to behavioral gains are largely unknown. This study tested whether a 50-h intervention which included both cognitive and social-cognitive training would influence neural mechanisms that support social ccognition. Schizophrenia participants completed a computer-based intervention of either auditory-based cognitive training (AT) plus social-cognition training (SCT) (N=11) or non-specific computer games (CG) (N=11). Assessments included a functional magnetic resonance imaging (fMRI) task of facial emotion recognition, and behavioral measures of cognition, social cognition, and functional outcome. The fMRI results showed the predicted group-by-time interaction. Results were strongest for emotion recognition of happy, surprise and fear relative to CG participants, AT+SCT participants showed a neural activity increase in bilateral amygdala, right putamen and right medial prefrontal cortex. Across all participants, pre-to-post intervention neural activity increase in these regions predicted behavioral improvement on an independent emotion perception measure (MSCEIT Perceiving Emotions). Among AT+SCT participants alone, neural activity increase in right amygdala predicted behavioral improvement in emotion perception. The findings indicate that combined cognition and social-cognition training improves neural systems that support social-cognition skills.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Psicologia do Esquizofrênico / Terapia Cognitivo-Comportamental / Emoções / Expressão Facial / Tonsila do Cerebelo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Psicologia do Esquizofrênico / Terapia Cognitivo-Comportamental / Emoções / Expressão Facial / Tonsila do Cerebelo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos