Differences in irradiation susceptibility and turnover between mucosal and connective tissue-type mast cells of mice.
Exp Hematol
; 18(7): 843-7, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-2379550
ABSTRACT
Although precursors of mast cells are derived from the bone marrow, phenotypes of mast cells are influenced by the tissues in which final differentiation occurs. Connective tissue-type mast cells (CTMC) and mucosal mast cells (MMC) are different in morphological, biochemical, immunological, and functional criteria. The purpose of the present study was to obtain information about the differentiation process of MMC. First, we compared changes in irradiation susceptibility in mice during the differentiation process of CTMC and MMC. The decrease in irradiation susceptibility was remarkable in the CTMC differentiation process, but it was moderate in that of MMC. Some morphologically identifiable CTMC in the peritoneal cavity had proliferative potential and were highly radioresistant, whereas such a radioresistant population of MMC was not detectable in the gastric mucosa. Second, we estimated the turnover of CTMC and MMC by determining the proportion of mast cells that were labeled with continuously administered bromodeoxyuridine. The turnover of MMC was significantly faster than that of CTMC. The absence of the radioresistant mast cell population in the gastric mucosa appeared to be related to the short life span of MMC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células do Tecido Conjuntivo
/
Mucosa Gástrica
/
Mastócitos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Exp Hematol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão