Predictors of diabetes mellitus and abnormal blood glucose in patients receiving opioid maintenance treatment.
Am J Addict
; 22(4): 411-6, 2013.
Article
em En
| MEDLINE
| ID: mdl-23795882
ABSTRACT
BACKGROUND:
Buprenorphine is a partial opioid agonist and may have less impact on the risk of developing diabetes mellitus (DM) compared to full opioid agonists like methadone.METHODS:
We conducted an observational retrospective study to investigate the predictable factors for impaired glucose tolerance and predisposition to DM in two groups of opiate addicts receiving long-term methadone maintenance treatment (MMT) [n = 58] or buprenorphine maintenance treatment (BMT) [n = 61].RESULTS:
In our cohort, being African American, hepatitis C positive status, elevated AST, and ALT, and being on methadone were significantly correlated to being diagnosed with DM. Among all those factors, being on methadone was most significantly related to being diagnosed with DM (χ² = 3.9888, p-value = .0458). The BMI was the only factor that was significantly correlated to having abnormal A1c level (χ² = 6.4229, p-value = .0113).CONCLUSIONS:
Buprenorphine may be less likely to contribute to the development of DM than methadone. More research is needed to understand the link between opioids and DM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Buprenorfina
/
Diabetes Mellitus
/
Tratamento de Substituição de Opiáceos
/
Metadona
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Addict
Assunto da revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos