Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.
Brain
; 136(Pt 10): 2937-51, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23811322
ABSTRACT
Contemporary research has revealed a great deal of information on the behaviours of microtubules that underlie critical events in the lives of neurons. Microtubules in the neuron undergo dynamic assembly and disassembly, bundling and splaying, severing, and rapid transport as well as integration with other cytoskeletal elements such as actin filaments. These various behaviours are regulated by signalling pathways that affect microtubule-related proteins such as molecular motor proteins and microtubule severing enzymes, as well as a variety of proteins that promote the assembly, stabilization and bundling of microtubules. In recent years, translational neuroscientists have earmarked microtubules as a promising target for therapy of injury and disease of the nervous system. Proof-of-principle has come mainly from studies using taxol and related drugs to pharmacologically stabilize microtubules in animal models of nerve injury and disease. However, concerns persist that the negative consequences of abnormal microtubule stabilization may outweigh the positive effects. Other potential approaches include microtubule-active drugs with somewhat different properties, but also expanding the therapeutic toolkit to include intervention at the level of microtubule regulatory proteins.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paclitaxel
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Microtúbulos
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Sistema Nervoso
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Doenças do Sistema Nervoso
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Revista:
Brain
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos