Two-stage hepatectomy after autologous CD133+ stem cells administration: a case report.
World J Surg Oncol
; 11(1): 192, 2013 Aug 13.
Article
em En
| MEDLINE
| ID: mdl-23941680
ABSTRACT
Liver resection is the mainstay of treatment for patients with primary and metastatic liver tumors. However, a large majority of patients present for initial medical evaluation with primary and metastatic liver tumors when their cancer is unresectable. Several trials have been undertaken to identify alternative treatments and complementary therapies. In the near future, the field of liver surgery will aim to increase the number of patients that can benefit from resection, since radical removal of the tumor currently provides the sole chance of cure. This paper reports the case of a patient with an advanced colonic cancer in the era of stem cell therapy. In 2011, a 57 years old white Caucasian man with a previous history of non-Hodgkin lymphoma (NHL) was diagnosed with colon cancer and bilobar liver metastases. Following neoadjuvant therapy, the patient was enrolled in a protocol of stem cell administration for liver regeneration. Surgery was initially performed on the primary cancer and left liver lobe. An extended right lobectomy to S1 was then performed after a portal vein embolization (PVE) and stem cell stimulation of the remaining liver. The postoperative course was uneventful and the patient was free of disease after 12 months. Extreme liver resection can provide a safer option and a chance of cure to otherwise unresectable patients when liver regeneration is boosted by PVE and stem cell administration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Linfoma não Hodgkin
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Glicoproteínas
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Antígenos CD
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Neoplasias do Colo
/
Transplante de Células-Tronco
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Hepatectomia
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Neoplasias Hepáticas
/
Regeneração Hepática
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
World J Surg Oncol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália