Life cycle analysis of solvent reduction in pharmaceutical synthesis using continuous adsorption for palladium removal.
J Environ Sci Health A Tox Hazard Subst Environ Eng
; 48(13): 1602-8, 2013.
Article
em En
| MEDLINE
| ID: mdl-23947697
ABSTRACT
The life cycle emissions associated with the reduction of wastes from an adsorption process to remove palladium complexes in drug manufacture have been evaluated. The study assessed a green improvement to a process step in an active pharmaceutical ingredient synthesis where palladium catalyst is removed from a reaction mixture. The greener process uses a continuous adsorption system, composed of a more efficient adsorbent, consuming less organic solvent and rinse water, which results in less waste disposal. The newer process is also more energy and cost efficient from an operational perspective. There is a 94% reduction in the carbon footprint of the new process when compared to the current operation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paládio
/
Solventes
/
Poluentes Químicos da Água
/
Eliminação de Resíduos Líquidos
/
Química Verde
Tipo de estudo:
Evaluation_studies
Idioma:
En
Revista:
J Environ Sci Health A Tox Hazard Subst Environ Eng
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos