The influence of angiotensin-(1-7) Mas receptor agonist (AVE 0991) on mitochondrial proteome in kidneys of apoE knockout mice.
Biochim Biophys Acta
; 1834(12): 2463-9, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23988828
Excessive action of angiotensin II on mitochondria has been shown to play an important role in mitochondrial dysfunction, a common feature of atherogenesis and kidney injury. Angiotensin-(1-7)/Mas receptor axis constitutes a countermeasure to the detrimental effects of angiotensin II on AT1 receptors. The aim of the study was to assess the effects of angiotensin-(1-7) peptidomimetic AVE0991 on the kidney mitochondrial proteome in widely used animal model of atherosclerosis (apoE(-/-) mice). Proteins changed in apoE(-/-) mice belonged to the groups of antioxidant enzymes, apoptosis regulators, inflammatory factors and metabolic enzymes. Importantly, AVE0991 partially reversed atherosclerosis-related changes in apoE(-/-) mice.
Palavras-chave
2DELCMS/MS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; ACE2; ADF; AT1r; AT2r; Ang II; Ang IV; Ang-(112); Ang-(17); Angiotensin (17); Apolipoprotein E; CA2; CHAPS; CKD; COX-IV; DTT; EGTA; ERK; ESRD; GPM; GRHPR; GST P1; HPLC; HRP; Hint1; IAA; IEF; IL-1; IPG; JNK; Kidney; MAP; MIF; Mitochondrion; MnSOD; NADPH; PAS; PDI; PH; PMSF; Proteomics; Prx 5; RAS; SDS; TFA; TPP; TTBS; The Global Proteome Machine; Tween-Tris-buffered saline; actin depolymerizing factor; angiotensin II; angiotensin IV; angiotensin converting enzyme 2; angiotensin-(112); angiotensin-(17); apoE(−/−); apolipoprotein E deficient mice; c-Jun N-terminal kinase; carbonic anhydrase 2; chronic kidney disease; cytochrome c oxidase subunit IV; ditiotreitol; end stage renal disease; ethylene glycol tetraacetic acid; extracellular signal-regulated kinases; glutathione S-transferase P1; glyoxylate reductase; high-pressure liquid chromatography; histidine triad nucleotide-binding protein 1; horseradish peroxidase; immobilized pH gradient strips; interleukin 1; iodoacetamide; isoelectrofocusing; macrophage inhibitory factor; manganese superoxide dismutase; mitogen-activated protein kinase; periodic acid-Schiff stain; peroxiredoxin-5; phenylmethylsulfonyl fluoride; primary hyperoxaluria; protein disulfide isomerase; reduced nicotinamide adenine dinucleotide phosphate; reninangiotensin system; sodium dodecyl sulfate; trans-proteomic pipeline; trifluoroacetic acid; two-dimensional electrophoresis coupled with liquid chromatography and tandem mass spectrometry; type 1 angiotensin II receptor; type 2 angiotensin II receptor
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
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Proteínas Proto-Oncogênicas
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Proteoma
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Proteínas Mitocondriais
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Receptores Acoplados a Proteínas G
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Aterosclerose
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Imidazóis
/
Rim
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Polônia