Your browser doesn't support javascript.
loading
Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis.
Freigang, Stefan; Ampenberger, Franziska; Weiss, Adrienne; Kanneganti, Thirumala-Devi; Iwakura, Yoichiro; Hersberger, Martin; Kopf, Manfred.
Afiliação
  • Freigang S; Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
Nat Immunol ; 14(10): 1045-53, 2013 Oct.
Article em En | MEDLINE | ID: mdl-23995233
Chronic inflammation is a fundamental aspect of metabolic disorders such as obesity, diabetes and cardiovascular disease. Cholesterol crystals are metabolic signals that trigger sterile inflammation in atherosclerosis, presumably by activating inflammasomes for IL-1ß production. We found here that atherogenesis was mediated by IL-1α and we identified fatty acids as potent inducers of IL-1α-driven vascular inflammation. Fatty acids selectively stimulated the release of IL-1α but not of IL-1ß by uncoupling mitochondrial respiration. Fatty acid-induced mitochondrial uncoupling abrogated IL-1ß secretion, which deviated the cholesterol crystal-elicited response toward selective production of IL-1α. Our findings delineate a previously unknown pathway for vascular immunopathology that links the cellular response to metabolic stress with innate inflammation, and suggest that IL-1α, not IL-1ß, should be targeted in patients with cardiovascular disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite / Aterosclerose / Interleucina-1alfa / Ácidos Graxos / Inflamassomos / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite / Aterosclerose / Interleucina-1alfa / Ácidos Graxos / Inflamassomos / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Suíça