New pyridocarbazole derivatives. Synthesis and their in vitro anticancer activity.
Acta Pol Pharm
; 70(5): 823-32, 2013.
Article
em En
| MEDLINE
| ID: mdl-24147360
ABSTRACT
In this paper, we describe our results of the synthesis and biological testing of analogues of the natural alkaloids olivacine and ellipticine. We have synthesized fourteen new 1-substituted pyrido[4,3-b]carbazole derivatives. All of them were tested in vitro for their anticancer activity on three human tumor cell lines CCRF/CEM (T lymphoblast leukemia), A549 (lung adenocarcinoma), and MCF7 (breast cancer). Cytotoxicity to non-cancer cells was estimated in cultures of the mice fibroblast cell line 3T3 BALB. The anticancer activity of 9-methoxy-5,6-dimethyl-1-[(1,1-bis-hydroxymethyI-propylamino)-methyl]-6H-pyrido[4,3-b]carbazole (compound 9) was the strongest amongst compounds tested on the three cancer cell lines; it was about 5 times higher than ellipticine and about 10% higher than doxorubicin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbazóis
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Pol Pharm
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Polônia