The similar expression pattern of MHC class I molecules in human and mouse cerebellar cortex.
Neurochem Res
; 39(1): 180-6, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24272393
ABSTRACT
The major histocompatibility complex (MHC) class I molecules are considered to be important in the immune system. However, the results reported in the past decade indicate that they also play important roles in the central nervous system. Here we examined the expression of MHC I and ß2-microglobulin (ß2m) in human and mouse cerebellar cortex. The results show that MHC I molecules are expressed both in human and mouse cerebellar cortex during brain development. The expression of H-2K(b)/D(b) is gradually increased with the development of mouse cerebellar cortex, but finally decreased to a very low level. Similarly, the expression of HLA-B/C genes is increased in developing human cerebellar cortex, but decreased after birth. The spatial and temporal expression of ß2m overlaps mostly with that of HLA-B/C molecules, and they are co-expressed in Purkinje cells. Our findings provide a fundamental basis to reveal the functions of neuronal MHC class I molecules in the development of human cerebellum.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe I
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Córtex Cerebelar
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Microglobulina beta-2
Limite:
Adult
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Animals
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Child, preschool
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Neurochem Res
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China