Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents.
Bioorg Med Chem Lett
; 24(1): 49-53, 2014 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-24360606
ABSTRACT
A set of α-quaternary 3-chloro-1-hydroxyalkylphosphonates, analogues of fosfomycin and fosfonochlorin, some of which are new compounds, was synthesized. The compounds were screened for bioactivity against several clinical and standard microbial isolates. Some were found to have moderate activity. The activity was higher with phenyl protection of the phosphoryl ester groups and α-phenyl substitution. Compound 11 was as effective or more potent than fosfomycin or chloramphenicol against several Gram-negative bacteria as well as against some Gram-positive ones.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Organofosfonatos
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Bactérias Gram-Negativas
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Bactérias Gram-Positivas
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Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article