The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy.
Rep Pract Oncol Radiother
; 16(6): 232-6, 2011.
Article
em En
| MEDLINE
| ID: mdl-24376986
ABSTRACT
BACKGROUND:
In spite of radical gastrectomy with resection of the lymphatic system, where no metastases are found during histopathological examination, about 30% of patients have relapse of the neoplastic process. This situation may be caused by micrometastases or isolated neoplastic cells in the lymphatic system which were not identified during a standard histopathological examination.AIM:
The aim of the study was to evaluate the clinical importance of micrometastases within the lymphatic system in patients with gastric cancer. MATERIALS ANDMETHODS:
A group of 20 patients treated for gastric cancer were subjected to retrospective analysis. Of all the patients who underwent surgery, a group with tumours classified as T1 or T2 was selected. No metastases within the lymphatic system were found in the standard evaluation - N0 mark. Paraffin-embedded blocks of lymph nodes were cut and new specimens were made, which were then stained again by means of immunohistochemistry. Antibodies against cytokeratin AE1/AE3 were used.RESULTS:
A total of 319 lymph nodes were assessed in 20 patients in an H + E examination. After the immunohistochemical examination, micrometastases within the lymphatic system were found in 4 (20%) patients and isolated neoplastic cells in other 4 (20%) patients.CONCLUSION:
On the basis of numerous publications and our own material, we think that the presence of micrometastases may be related to a worse prognosis. The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Rep Pract Oncol Radiother
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Polônia